CMap Candidate Details

Structure:
CMap ID: C02227
Pert ID: BRD-A92537424
Compound Name: danazol
Targets: ESR1; GNRHR
MoA: Estrogen receptor antagonist; Progesterone receptor agonist
SMILES: C[C@]12CCC3C(CCC4=Cc5oncc5C[C@]34C)C1CC[C@@]2(O)C#C
InchiKey: POZRVZJJTULAOH-GSQPBCFPSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5560 BRD-A92537424 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6500 BRD-A92537424 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.99 0.51
42241 BRD-A92537424 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42581 BRD-A92537424 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43439 BRD-A92537424 NPC 10 uM 24 h 0.24 0.99 0.1 -0.41 -1.39 2.02
43747 BRD-A92537424 PHH 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.24
95328 BRD-A92537424 A549 10 uM 48 h -0.29 -1.23 0.63 -0.26 -0.86 0.21
95371 BRD-A92537424 MCF??7.00 10 uM 48 h -0.22 -0.91 0.05 0.0 0.0 0.0
95479 BRD-A92537424 U2OS 0.12 uM 6 h -0.25 -1.05 0.24 -0.33 -1.11 0.92
128415 BRD-A92537424 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128491 BRD-A92537424 HT29 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128524 BRD-A92537424 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128580 BRD-A92537424 MCF10A 10 uM 24 h -0.21 -0.87 0.02 0.0 0.0 0.0
128618 BRD-A92537424 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.29
128670 BRD-A92537424 PC3 0.125 uM 24 h 0.0 0.0 0.0 0.29 1.02 0.47
128697 BRD-A92537424 THP1 0.125 uM 24 h 0.0 0.0 0.0 0.23 0.82 0.1
136160 BRD-A92537424 A375 0.03 uM 24 h -0.2 -0.85 0.01 0.41 1.45 2.22
136205 BRD-A92537424 HA1E 0.01 uM 24 h 0.0 0.0 0.0 0.28 0.97 0.36
136248 BRD-A92537424 HELA 0.25 uM 24 h 0.34 1.42 1.09 -0.31 -1.06 0.73
136377 BRD-A92537424 YAPC 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).