CMap Candidate Details

Structure:
CMap ID: C02230
Pert ID: BRD-A92630576
Compound Name: trimebutine
Targets: OPRD1; OPRK1; OPRM1
MoA: Opioid receptor agonist
SMILES: CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(N(C)C)c1ccccc1
InchiKey: LORDFXWUHHSAQU-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
25311 BRD-A92630576 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.64
128097 BRD-A92630576 A375 0.04 uM 24 h 0.2 0.84 0.0 0.3 1.06 0.61
128126 BRD-A92630576 A549 0.125 uM 24 h 0.34 1.41 1.03 0.0 0.0 0.0
128159 BRD-A92630576 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.57
128178 BRD-A92630576 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128198 BRD-A92630576 MCF10A 1.11 uM 24 h 0.19 0.81 0.0 0.0 0.0 0.0
128276 BRD-A92630576 MDAMB231 0.125 uM 24 h -0.28 -1.15 0.44 0.37 1.33 1.72
135788 BRD-A92630576 HA1E 2.22 uM 24 h 0.24 0.99 0.09 0.0 0.0 0.0
135872 BRD-A92630576 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.24
135960 BRD-A92630576 JURKAT 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136016 BRD-A92630576 MCF??7.00 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136043 BRD-A92630576 PC3 0.08 uM 24 h 0.26 1.09 0.23 -0.17 -0.57 0.0
136075 BRD-A92630576 THP1 0.74 uM 24 h -0.26 -1.07 0.27 0.0 0.0 0.0
136106 BRD-A92630576 YAPC 0.01 uM 24 h -0.23 -0.96 0.09 -0.29 -0.98 0.49
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).