CMap Candidate Details

Structure:
CMap ID: C22318
Pert ID: BRD-K62609077
Compound Name: scoulerine
Targets: ADRA1D; ADRA2A; GABRA1
MoA: GABA receptor antagonist; Serotonin receptor antagonist; Adrenergic receptor antagonist
SMILES: COc1ccc2C[C@@H]3N(CCc4cc(OC)c(O)cc34)Cc2c1O
InchiKey: KNWVMRVOBAFFMH-HNNXBMFYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1765 BRD-K62609077 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
1935 BRD-K62609077 HCC515 10 uM 24 h -0.22 -0.92 0.06 0.0 0.0 0.0
2175 BRD-K62609077 PC3 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.25 1.35
2473 BRD-K62609077 VCAP 10 uM 24 h 0.21 0.86 0.01 0.23 0.81 0.09
41812 BRD-K62609077 A375 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.98 0.48
41963 BRD-K62609077 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42423 BRD-K62609077 ASC 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.7
42739 BRD-K62609077 HEPG2 10 uM 6 h 0.24 0.98 0.09 0.4 1.43 2.21
43039 BRD-K62609077 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43218 BRD-K62609077 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.26 1.39
43604 BRD-K62609077 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43906 BRD-K62609077 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44163 BRD-K62609077 SKB 10 uM 24 h 0.18 0.74 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).