CMap Candidate Details

Structure:
CMap ID: C22339
Pert ID: BRD-K62685538
Compound Name: triptorelin
Targets: GNRHR
MoA: Gonadotropin releasing factor hormone receptor agonist
SMILES: CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O
InchiKey: VXKHXGOKWPXYNA-PGBVPBMZSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
124931 BRD-K62685538 A375 0.04 uM 24 h 0.26 1.1 0.24 -0.41 -1.39 2.02
124959 BRD-K62685538 A549 0.04 uM 24 h 0.0 0.0 0.0 0.31 1.1 0.69
125019 BRD-K62685538 HELA 0.04 uM 24 h 0.32 1.35 0.96 0.0 0.0 0.0
125051 BRD-K62685538 HT29 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125069 BRD-K62685538 MCF10A 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125103 BRD-K62685538 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.95
125129 BRD-K62685538 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.27 0.94 0.29
125150 BRD-K62685538 THP1 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125199 BRD-K62685538 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133009 BRD-K62685538 HA1E 0.03 uM 24 h -0.27 -1.12 0.39 -0.46 -1.54 15.35
133036 BRD-K62685538 HEK293 2.22 uM 24 h 0.0 0.0 0.0 -0.36 -1.22 1.25
133143 BRD-K62685538 JURKAT 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133217 BRD-K62685538 MCF??7.00 0.74 uM 24 h 0.31 1.3 0.72 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).