CMap Candidate Details

Structure:
CMap ID: C22390
Pert ID: BRD-K62810658
Compound Name: PD-98059
Targets: MAP2K1
MoA: MEK inhibitor; MAP kinase inhibitor
SMILES: COc1cccc(-c2cc(=O)c3ccccc3o2)c1N
InchiKey: QFWCYNPOPKQOKV-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3248 BRD-K62810658 HCC515 10 uM 24 h 0.0 0.0 0.0 0.34 1.21 1.15
9467 BRD-K62810658 AGS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9774 BRD-K62810658 H1299 10 uM 6 h -0.24 -1.0 0.15 0.0 0.0 0.0
10069 BRD-K62810658 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10557 BRD-K62810658 HCT116 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11533 BRD-K62810658 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12832 BRD-K62810658 SW480 10 uM 6 h 0.0 0.0 0.0 0.37 1.31 1.59
12943 BRD-K62810658 THP1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13651 BRD-K62810658 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44998 BRD-K62810658 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45289 BRD-K62810658 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.28 1.0 0.43
45709 BRD-K62810658 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.25
46112 BRD-K62810658 NPC 10 uM 24 h -0.21 -0.86 0.02 0.0 0.0 0.0
46753 BRD-K62810658 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53600 BRD-K62810658 HUH7 20 uM 6 h -0.21 -0.89 0.03 0.43 1.51 2.27
53682 BRD-K62810658 PHH 20 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.58
96307 BRD-K62810658 A375 10 uM 24 h 0.18 0.76 0.0 0.35 1.22 1.16
96378 BRD-K62810658 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97249 BRD-K62810658 HAP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99068 BRD-K62810658 NEU 10 uM 6 h 0.22 0.92 0.04 0.0 0.0 0.0
99312 BRD-K62810658 U2OS 20 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
115665 BRD-K62810658 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115832 BRD-K62810658 HT29 10 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.25
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).