CMap Candidate Details

Structure:
CMap ID: C02243
Pert ID: BRD-A93236127
Compound Name: digitoxin
Targets: ATP1A1
MoA: ATPase inhibitor
SMILES: C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)O[C@H]1[C@@H](O)C[C@H](O[C@H]2[C@@H](O)C[C@H](O[C@H]3CC[C@@]4(C)[C@H](CCC5C4CC[C@]4(C)[C@H](CC[C@]54O)C4=CC(=O)OC4)C3)O[C@@H]2C)O[C@@H]1C
InchiKey: WDJUZGPOPHTGOT-KSVSUYAUSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1217 BRD-A93236127 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1252 BRD-A93236127 A549 0.12 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
1293 BRD-A93236127 MCF??7.00 0.12 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
1325 BRD-A93236127 U2OS 0.12 uM 24 h 0.0 0.0 0.0 -0.27 -0.89 0.27
5172 BRD-A93236127 A375 10 uM 6 h 0.0 0.0 0.0 -0.48 -1.6 15.65
5290 BRD-A93236127 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5563 BRD-A93236127 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5868 BRD-A93236127 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6502 BRD-A93236127 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42242 BRD-A93236127 ASC 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.19 1.16
42888 BRD-A93236127 HT29 10 uM 6 h 0.23 0.96 0.07 -0.52 -1.74 15.65
43440 BRD-A93236127 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44032 BRD-A93236127 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).