CMap Candidate Details

Structure:
CMap ID: C22438
Pert ID: BRD-K62965247
Compound Name: tipifarnib-P2
Targets: FNTA; FNTB
MoA: Farnesyltransferase inhibitor
SMILES: Cn1cncc1[C@@](N)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1
InchiKey: PLHJCIYEEKOWNM-HHHXNRCGSA-N
Compound Aliases: TIPIFARNIB-P2

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9109 BRD-K62965247 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9468 BRD-K62965247 AGS 10 uM 6 h 0.0 0.0 0.0 0.33 1.18 0.98
9775 BRD-K62965247 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10234 BRD-K62965247 HCC515 10 uM 24 h -0.29 -1.2 0.55 0.0 0.0 0.0
10558 BRD-K62965247 HCT116 10 uM 6 h 0.0 0.0 0.0 0.21 0.75 0.04
10817 BRD-K62965247 HEPG2 10 uM 6 h 0.24 0.99 0.1 0.45 1.58 2.35
11534 BRD-K62965247 NCIH2073 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.98 0.48
11802 BRD-K62965247 NCIH508 10 uM 6 h 0.0 0.0 0.0 -0.4 -1.33 1.74
12096 BRD-K62965247 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12833 BRD-K62965247 SW480 10 uM 6 h 0.0 0.0 0.0 -0.23 -0.78 0.09
13320 BRD-K62965247 U937 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13490 BRD-K62965247 VCAP 10 uM 24 h -0.29 -1.19 0.55 0.0 0.0 0.0
124575 BRD-K62965247 A375 10 uM 24 h 0.0 0.0 0.0 0.32 1.14 0.86
124612 BRD-K62965247 HA1E 0.37 uM 24 h 0.2 0.85 0.01 0.0 0.0 0.0
124637 BRD-K62965247 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124688 BRD-K62965247 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.39 1.38 2.16
124741 BRD-K62965247 MCF10A 3.33 uM 24 h 0.21 0.87 0.01 0.26 0.93 0.27
124757 BRD-K62965247 MCF??7.00 3.33 uM 24 h -0.18 -0.75 0.0 0.0 0.0 0.0
124791 BRD-K62965247 MDAMB231 10 uM 24 h 0.25 1.06 0.18 0.35 1.24 1.24
124832 BRD-K62965247 PC3 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.39
124874 BRD-K62965247 THP1 10 uM 24 h 0.33 1.36 0.97 0.0 0.0 0.0
132785 BRD-K62965247 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132830 BRD-K62965247 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.37
132948 BRD-K62965247 YAPC 2.22 uM 24 h -0.27 -1.12 0.38 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).