CMap Candidate Details

Structure:
CMap ID: C22446
Pert ID: BRD-K62982419
Compound Name: cilomilast
Targets: PDE4A; PDE4B; PDE4D
MoA: Phosphodiesterase inhibitor
SMILES: COc1ccc(cc1OC1CCCC1)[C@@]1(CC[C@@H](CC1)C(O)=O)C#N
InchiKey: CFBUZOUXXHZCFB-LDTOLXSISA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
29904 BRD-K62982419 A375 10 uM 6 h 0.0 0.0 0.0 -0.34 -1.13 0.99
30224 BRD-K62982419 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
30504 BRD-K62982419 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
30802 BRD-K62982419 HA1E 10 uM 6 h 0.0 0.0 0.0 -0.26 -0.88 0.25
31402 BRD-K62982419 HEPG2 10 uM 6 h 0.33 1.36 0.97 0.0 0.0 0.0
31509 BRD-K62982419 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31900 BRD-K62982419 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
32483 BRD-K62982419 NPC 10 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.16
32806 BRD-K62982419 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
33086 BRD-K62982419 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33327 BRD-K62982419 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).