CMap Candidate Details

Structure:
CMap ID: C02249
Pert ID: BRD-A93424738
Compound Name: dexamethasone-acetate
Targets: NR3C1
MoA: Corticosteroid agonist; Cytochrome P450 inhibitor; Glucocorticoid receptor agonist
SMILES: C[C@@H]1CC2C3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COC(C)=O
InchiKey: AKUJBENLRBOFTD-HIBZCRSPSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5564 BRD-A93424738 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.28
5869 BRD-A93424738 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.22 0.77 0.06
6503 BRD-A93424738 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42035 BRD-A93424738 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42243 BRD-A93424738 ASC 10 uM 24 h -0.27 -1.11 0.37 -0.31 -1.03 0.65
43441 BRD-A93424738 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43748 BRD-A93424738 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44033 BRD-A93424738 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128429 BRD-A93424738 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128474 BRD-A93424738 HELA 0.37 uM 24 h -0.27 -1.13 0.4 0.0 0.0 0.0
128500 BRD-A93424738 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128539 BRD-A93424738 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128632 BRD-A93424738 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128712 BRD-A93424738 THP1 0.125 uM 24 h -0.31 -1.29 0.77 0.0 0.0 0.0
128759 BRD-A93424738 YAPC 1.11 uM 24 h -0.31 -1.29 0.77 0.0 0.0 0.0
136172 BRD-A93424738 A375 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136218 BRD-A93424738 HA1E 0.25 uM 24 h -0.31 -1.29 0.77 -0.46 -1.55 15.35
136308 BRD-A93424738 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136338 BRD-A93424738 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136361 BRD-A93424738 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).