CMap Candidate Details

Structure:
CMap ID: C22506
Pert ID: BRD-K63178091
Compound Name: telotristat
Targets: TPH1
MoA: Serotonin release inhibitor; Serotonin receptor antagonist
SMILES: Cc1ccn(n1)-c1cc(Cl)ccc1[C@@H](Oc1cc(nc(N)n1)-c1ccc(C[C@H](N)C(O)=O)cc1)C(F)(F)F
InchiKey: NCLGDOBQAWBXRA-PGRDOPGGSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
124935 BRD-K63178091 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125156 BRD-K63178091 THP1 0.37 uM 24 h 0.27 1.11 0.25 0.34 1.19 1.03
125204 BRD-K63178091 YAPC 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.09 0.82
132994 BRD-K63178091 A549 0.01 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.34
133012 BRD-K63178091 HA1E 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133042 BRD-K63178091 HEK293 0.01 uM 24 h 0.25 1.05 0.17 -0.39 -1.3 1.62
133087 BRD-K63178091 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133114 BRD-K63178091 HT29 0.08 uM 24 h 0.22 0.9 0.03 -0.24 -0.82 0.15
133149 BRD-K63178091 JURKAT 0.01 uM 24 h -0.23 -0.95 0.09 0.0 0.0 0.0
133194 BRD-K63178091 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133222 BRD-K63178091 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.9
133256 BRD-K63178091 MDAMB231 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133287 BRD-K63178091 PC3 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).