CMap Candidate Details

Structure:
CMap ID: C22554
Pert ID: BRD-K63343048
Compound Name: orlistat
Targets: FASN; PNLIP; DAGLA; LIPF
MoA: Lipase inhibitor
SMILES: CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O
InchiKey: AHLBNYSZXLDEJQ-FWEHEUNISA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
24596 BRD-K63343048 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
25177 BRD-K63343048 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
25404 BRD-K63343048 VCAP 10 uM 24 h 0.23 0.96 0.07 0.0 0.0 0.0
124936 BRD-K63343048 A375 1.11 uM 24 h -0.18 -0.77 0.0 0.0 0.0 0.0
124996 BRD-K63343048 HA1E 0.125 uM 24 h 0.29 1.22 0.48 0.0 0.0 0.0
125023 BRD-K63343048 HELA 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125054 BRD-K63343048 HT29 3.33 uM 24 h 0.29 1.19 0.42 0.0 0.0 0.0
125160 BRD-K63343048 THP1 0.125 uM 24 h 0.0 0.0 0.0 0.35 1.25 1.28
125206 BRD-K63343048 YAPC 3.33 uM 24 h -0.21 -0.86 0.02 0.0 0.0 0.0
133046 BRD-K63343048 HEK293 0.08 uM 24 h 0.0 0.0 0.0 -0.38 -1.28 1.45
133153 BRD-K63343048 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 -0.23 -0.77 0.08
133195 BRD-K63343048 MCF10A 0.03 uM 24 h 0.25 1.05 0.17 0.24 0.85 0.14
133225 BRD-K63343048 MCF??7.00 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133258 BRD-K63343048 MDAMB231 0.74 uM 24 h 0.21 0.89 0.02 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).