CMap Candidate Details

Structure:
CMap ID: C22585
Pert ID: BRD-K63430059
Compound Name: methoxsalen
Targets: CYP1A1; CYP1A2; CYP2A6; CYP2A13; CYP3A4
MoA: DNA synthesis inhibitor
SMILES: COc1c2occc2cc2ccc(=O)oc12
InchiKey: QXKHYNVANLEOEG-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6793 BRD-K63430059 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
7477 BRD-K63430059 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7907 BRD-K63430059 HT29 10 uM 24 h 0.0 0.0 0.0 0.24 0.84 0.13
8717 BRD-K63430059 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124962 BRD-K63430059 A549 0.04 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.6
125073 BRD-K63430059 MCF10A 1.11 uM 24 h 0.25 1.06 0.18 0.0 0.0 0.0
125158 BRD-K63430059 THP1 3.33 uM 24 h 0.3 1.24 0.53 0.33 1.15 0.89
125205 BRD-K63430059 YAPC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133044 BRD-K63430059 HEK293 0.03 uM 24 h 0.0 0.0 0.0 -0.33 -1.13 0.97
133089 BRD-K63430059 HELA 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133151 BRD-K63430059 JURKAT 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133224 BRD-K63430059 MCF??7.00 0.01 uM 24 h 0.28 1.18 0.39 0.0 0.0 0.0
133257 BRD-K63430059 MDAMB231 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133289 BRD-K63430059 PC3 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).