CMap Candidate Details

Structure:
CMap ID: C22611
Pert ID: BRD-K63504947
Compound Name: semaxanib
Targets: FLT1; KDR; KIT; PDGFRB
MoA: VEGFR inhibitor
SMILES: Cc1cc(C)c(C=C2/C(=O)Nc3ccccc23)[nH]1
InchiKey: WUWDLXZGHZSWQZ-WQLSENKSSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4456 BRD-K63504947 HCC515 10 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.38
4946 BRD-K63504947 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.09 0.81
39730 BRD-K63504947 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40027 BRD-K63504947 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.99 0.5
40841 BRD-K63504947 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41148 BRD-K63504947 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41486 BRD-K63504947 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95610 BRD-K63504947 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.44 -1.47 15.35
95639 BRD-K63504947 U2OS 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124964 BRD-K63504947 A549 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125024 BRD-K63504947 HELA 10 uM 24 h -0.17 -0.72 0.0 0.0 0.0 0.0
125075 BRD-K63504947 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125161 BRD-K63504947 THP1 10 uM 24 h -0.27 -1.1 0.36 0.0 0.0 0.0
132978 BRD-K63504947 A375 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133013 BRD-K63504947 HA1E 0.25 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.14
133047 BRD-K63504947 HEK293 0.08 uM 24 h 0.0 0.0 0.0 -0.36 -1.21 1.22
133115 BRD-K63504947 HT29 2.22 uM 24 h 0.29 1.2 0.43 0.0 0.0 0.0
133154 BRD-K63504947 JURKAT 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133259 BRD-K63504947 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 -0.37 -1.25 1.35
133290 BRD-K63504947 PC3 2.22 uM 24 h 0.23 0.96 0.07 0.0 0.0 0.0
133314 BRD-K63504947 YAPC 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).