CMap Candidate Details

Structure:
CMap ID: C22723
Pert ID: BRD-K63861289
Compound Name: molsidomine
Targets: GUCY1A1
MoA: Guanylyl cyclase activator
SMILES: CCOC(=O)Nc1c[n+](no1)N1CCOCC1
InchiKey: XLFWDASMENKTKL-UHFFFAOYSA-O
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
99325 BRD-K63861289 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
124588 BRD-K63861289 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124630 BRD-K63861289 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124675 BRD-K63861289 HELA 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124710 BRD-K63861289 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124749 BRD-K63861289 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124859 BRD-K63861289 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124900 BRD-K63861289 THP1 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132706 BRD-K63861289 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132773 BRD-K63861289 HEK293 0.25 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.39
132847 BRD-K63861289 JURKAT 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132912 BRD-K63861289 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 0.34 1.19 1.03
132922 BRD-K63861289 MDAMB231 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132969 BRD-K63861289 YAPC 0.25 uM 24 h 0.0 0.0 0.0 0.32 1.13 0.82
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).