CMap Candidate Details

Structure:
CMap ID: C22843
Pert ID: BRD-K64245000
Compound Name: GW-4064
Targets: NR1H4
MoA: FXR agonist
SMILES: CC(C)c1onc(c1COc2ccc(C=Cc3cccc(c3)C(=O)O)c(Cl)c2)c4c(Cl)cccc4Cl
InchiKey: BYTNEISLBIENSA-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5223 BRD-K64245000 A375 10 uM 6 h 0.0 0.0 0.0 0.28 1.0 0.42
5473 BRD-K64245000 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5794 BRD-K64245000 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5942 BRD-K64245000 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6046 BRD-K64245000 HT29 10 uM 6 h 0.0 0.0 0.0 -0.19 -0.65 0.01
6209 BRD-K64245000 PC3 10 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
6579 BRD-K64245000 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37407 BRD-K64245000 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37711 BRD-K64245000 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38233 BRD-K64245000 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38533 BRD-K64245000 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38986 BRD-K64245000 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99330 BRD-K64245000 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).