CMap Candidate Details

Structure:
CMap ID: C22896
Pert ID: BRD-K64402243
Compound Name: ivachtin
Targets: CASP3
MoA: Caspase inhibitor
SMILES: CC(=O)OCCN1C(=O)c2c(C1=O)c3cc(ccc3nc2C)S(=O)(=O)N4CCOCC4
InchiKey: MWXJJTMEUGWKKY-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2476 BRD-K64402243 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42126 BRD-K64402243 A549 10 uM 6 h 0.0 0.0 0.0 -0.23 -0.77 0.08
42433 BRD-K64402243 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43613 BRD-K64402243 NPC 10 uM 24 h -0.2 -0.83 0.0 0.0 0.0 0.0
43915 BRD-K64402243 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115946 BRD-K64402243 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116025 BRD-K64402243 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116064 BRD-K64402243 HCC515 3.33 uM 24 h -0.27 -1.13 0.4 -0.24 -0.82 0.15
116107 BRD-K64402243 HEPG2 0.125 uM 24 h 0.27 1.13 0.3 0.0 0.0 0.0
116153 BRD-K64402243 HT29 3.33 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.33
116197 BRD-K64402243 MCF??7.00 0.37 uM 24 h -0.2 -0.85 0.01 0.0 0.0 0.0
116234 BRD-K64402243 PC3 3.33 uM 24 h 0.23 0.97 0.08 0.25 0.88 0.18
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).