CMap Candidate Details

Structure:
CMap ID: C22970
Pert ID: BRD-K64606589
Compound Name: apicidin
Targets: HDAC6; HDAC5; HDAC1; HDAC2; HDAC7; HDAC8; HDAC11; HDAC10; HDAC3; HDAC9; HDAC4
MoA: HDAC inhibitor
SMILES: CC[C@@H](C)[C@@H]1NC(=O)[C@H](Cc2cn(OC)c3ccccc23)NC(=O)[C@H](CCCCCC(=O)CC)NC(=O)[C@H]4CCCCN4C1=O
InchiKey: JWOGUUIOCYMBPV-VWIQTCEGSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
30227 BRD-K64606589 A549 10 uM 6 h -0.21 -0.89 0.03 0.0 0.0 0.0
30512 BRD-K64606589 ASC 10 uM 24 h 0.0 0.0 0.0 -0.4 -1.35 2.02
33095 BRD-K64606589 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33333 BRD-K64606589 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98765 BRD-K64606589 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98921 BRD-K64606589 NEU 10 uM 24 h 0.19 0.8 0.0 0.0 0.0 0.0
119410 BRD-K64606589 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119471 BRD-K64606589 HA1E 3.33 uM 24 h -0.19 -0.79 0.0 0.0 0.0 0.0
119509 BRD-K64606589 HCC515 0.12 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.5
119546 BRD-K64606589 HEPG2 3.33 uM 24 h -0.2 -0.84 0.01 0.0 0.0 0.0
119578 BRD-K64606589 HT29 0.12 uM 24 h 0.0 0.0 0.0 -0.21 -0.71 0.03
119606 BRD-K64606589 MCF??7.00 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119639 BRD-K64606589 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).