CMap Candidate Details

Structure:
CMap ID: C22973
Pert ID: BRD-K64610608
Compound Name: EMF-BCA1-57
Targets: CASP3
MoA: Caspase inhibitor
SMILES: COc1ccc(cc1)S(=O)(=O)N(C)C[C@@H]2Oc3c(NC(=O)Nc4cccc5ccccc45)cccc3C(=O)N(C[C@H]2C)[C@@H](C)CO
InchiKey: FXIXTIXYCSOXIT-UDKTZTBJSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
19749 BRD-K64610608 HA1E 10 uM 6 h 0.23 0.97 0.08 0.0 0.0 0.0
34145 BRD-K64610608 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35596 BRD-K64610608 NEU 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.09 0.82
35816 BRD-K64610608 NPC 10 uM 24 h -0.23 -0.95 0.09 -0.24 -0.82 0.14
36307 BRD-K64610608 PHH 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.76 0.07
36605 BRD-K64610608 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36984 BRD-K64610608 VCAP 10 uM 6 h 0.0 0.0 0.0 0.26 0.92 0.24
116676 BRD-K64610608 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116718 BRD-K64610608 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116806 BRD-K64610608 HCC515 10 uM 24 h -0.22 -0.91 0.05 -0.24 -0.79 0.11
116849 BRD-K64610608 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.26
116898 BRD-K64610608 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116940 BRD-K64610608 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.06 0.74
116983 BRD-K64610608 PC3 10 uM 24 h 0.0 0.0 0.0 0.18 0.65 0.01
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).