CMap Candidate Details

Structure:
CMap ID: C22979
Pert ID: BRD-K64622987
Compound Name: torcetrapib
Targets: CETP
MoA: Cholesteryl ester transfer protein inhibitor
SMILES: CCOC(=O)N1[C@H](CC)C[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)OC)c2cc(ccc12)C(F)(F)F
InchiKey: CMSGWTNRGKRWGS-WIYYLYMNSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
124970 BRD-K64622987 A549 10 uM 24 h 0.22 0.9 0.02 0.36 1.28 1.37
125002 BRD-K64622987 HA1E 3.33 uM 24 h 0.0 0.0 0.0 -0.44 -1.47 15.35
125031 BRD-K64622987 HELA 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125133 BRD-K64622987 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125168 BRD-K64622987 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125211 BRD-K64622987 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132981 BRD-K64622987 A375 2.22 uM 24 h -0.24 -1.01 0.16 -0.37 -1.26 1.35
133055 BRD-K64622987 HEK293 0.08 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.21
133120 BRD-K64622987 HT29 0.25 uM 24 h -0.19 -0.8 0.0 0.24 0.85 0.14
133162 BRD-K64622987 JURKAT 0.74 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.12
133200 BRD-K64622987 MCF10A 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133229 BRD-K64622987 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133262 BRD-K64622987 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).