CMap Candidate Details

Structure:
CMap ID: C23000
Pert ID: BRD-K64670467
Compound Name: JNJ-16259685
Targets: GRM1
MoA: Glutamate receptor antagonist
SMILES: COC1CCC(CC1)C(=O)c2ccc3nc4OCCCc4cc3c2
InchiKey: QOTAQTRFJWLFCR-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1767 BRD-K64670467 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
1941 BRD-K64670467 HCC515 10 uM 24 h -0.23 -0.96 0.1 0.0 0.0 0.0
2180 BRD-K64670467 PC3 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.78
2478 BRD-K64670467 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41821 BRD-K64670467 A375 10 uM 6 h 0.0 0.0 0.0 0.3 1.05 0.58
42127 BRD-K64670467 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42434 BRD-K64670467 ASC 10 uM 24 h 0.27 1.13 0.3 0.0 0.0 0.0
42749 BRD-K64670467 HEPG2 10 uM 6 h -0.35 -1.45 1.43 0.0 0.0 0.0
43048 BRD-K64670467 HT29 10 uM 6 h -0.27 -1.14 0.42 0.22 0.79 0.08
43220 BRD-K64670467 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43614 BRD-K64670467 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43916 BRD-K64670467 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44171 BRD-K64670467 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98551 BRD-K64670467 NEU 10 uM 6 h 0.0 0.0 0.0 -0.36 -1.23 1.25
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).