CMap Candidate Details

Structure:
CMap ID: C23044
Pert ID: BRD-K64800655
Compound Name: PHA-793887
Targets: CDK2; CDK4; CDK5; CDK7; CDK9; CDK1
MoA: CDK inhibitor
SMILES: CC(C)CC(=O)Nc1n[nH]c2c1CN(C(=O)C1CCN(C)CC1)C2(C)C
InchiKey: HUXYBQXJVXOMKX-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1151 BRD-K64800655 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1205 BRD-K64800655 PC3 1.11 uM 24 h -0.19 -0.79 0.0 0.0 0.0 0.0
34146 BRD-K64800655 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34656 BRD-K64800655 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34925 BRD-K64800655 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35597 BRD-K64800655 NEU 10 uM 24 h 0.24 1.01 0.12 -0.31 -1.03 0.64
35817 BRD-K64800655 NPC 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.24 1.33
36308 BRD-K64800655 PHH 10 uM 24 h 0.25 1.05 0.17 0.0 0.0 0.0
36606 BRD-K64800655 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36985 BRD-K64800655 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91549 BRD-K64800655 BT20 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91582 BRD-K64800655 HS578T 2.22 uM 24 h 0.0 0.0 0.0 0.4 1.41 2.18
91660 BRD-K64800655 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92494 BRD-K64800655 HA1E 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92528 BRD-K64800655 HME1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92626 BRD-K64800655 HT29 0.12 uM 24 h -0.27 -1.11 0.36 -0.28 -0.94 0.37
92662 BRD-K64800655 LNCAP 3.33 uM 24 h -0.3 -1.25 0.69 0.0 0.0 0.0
92712 BRD-K64800655 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.47
92787 BRD-K64800655 MDAMB231 0.37 uM 3 h 0.0 0.0 0.0 -0.24 -0.8 0.12
92824 BRD-K64800655 SKBR3 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95427 BRD-K64800655 U2OS 1.11 uM 48 h 0.23 0.95 0.07 0.0 0.0 0.0
97252 BRD-K64800655 HAP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125033 BRD-K64800655 HELA 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125172 BRD-K64800655 THP1 3.33 uM 24 h 0.19 0.81 0.0 -0.33 -1.12 0.94
132983 BRD-K64800655 A375 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133060 BRD-K64800655 HEK293 2.22 uM 24 h -0.17 -0.73 0.0 0.0 0.0 0.0
133167 BRD-K64800655 JURKAT 2.22 uM 24 h 0.23 0.95 0.06 0.0 0.0 0.0
133320 BRD-K64800655 YAPC 2.22 uM 24 h 0.21 0.89 0.02 0.35 1.23 1.21
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).