CMap Candidate Details

Structure:
CMap ID: C23054
Pert ID: BRD-K64835161
Compound Name: ML-167
Targets: CLK1; DYRK1A; CLK4; DYRK1B
MoA: CLK inhibitor; DYRK inhibitor
SMILES: Cc1ccc(CNc2ncnc3ccc(cc23)-c2ccc(CO)o2)o1
InchiKey: ROCFOIBAEVAOLQ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
22039 BRD-K64835161 A375 10 uM 6 h 0.0 0.0 0.0 -0.22 -0.76 0.07
22318 BRD-K64835161 A549 10 uM 6 h -0.28 -1.15 0.44 0.0 0.0 0.0
23613 BRD-K64835161 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.22 1.24
24019 BRD-K64835161 PC3 10 uM 6 h 0.0 0.0 0.0 -0.4 -1.35 2.02
24188 BRD-K64835161 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115152 BRD-K64835161 U2OS 20 uM 6 h 0.0 0.0 0.0 -0.33 -1.11 0.92
118775 BRD-K64835161 HA1E 3.33 uM 24 h 0.22 0.91 0.03 -0.32 -1.07 0.76
118815 BRD-K64835161 HCC515 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118858 BRD-K64835161 HEPG2 10 uM 24 h -0.22 -0.9 0.05 0.25 0.87 0.17
118900 BRD-K64835161 HT29 3.33 uM 24 h 0.0 0.0 0.0 -0.39 -1.3 1.57
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).