CMap Candidate Details

Structure:
CMap ID: C23058
Pert ID: BRD-K64857848
Compound Name: XMD-885
Targets: LRRK2; MAPK7
MoA: MAP kinase inhibitor; Leucine rich repeat kinase inhibitor
SMILES: COc1cc(ccc1Nc1ncc2N(C)C(=O)c3ccccc3N(C)c2n1)N1CCN(C)CC1
InchiKey: DDTPGANIPBKTNU-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
34657 BRD-K64857848 HCC515 10 uM 6 h -0.23 -0.94 0.08 0.0 0.0 0.0
35175 BRD-K64857848 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35333 BRD-K64857848 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36309 BRD-K64857848 PHH 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.16 1.11
36607 BRD-K64857848 SKB 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.32
36986 BRD-K64857848 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.41 -1.37 2.02
91821 BRD-K64857848 HS578T 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91847 BRD-K64857848 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91943 BRD-K64857848 SKBR3 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.15
92859 BRD-K64857848 A375 3.33 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.14
92885 BRD-K64857848 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92912 BRD-K64857848 ASC 10 uM 24 h -0.2 -0.82 0.0 -0.26 -0.86 0.21
92969 BRD-K64857848 CD34 10 uM 24 h 0.24 1.0 0.11 0.0 0.0 0.0
93027 BRD-K64857848 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93060 BRD-K64857848 HEK293 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.95
93111 BRD-K64857848 HELA 10 uM 24 h 0.25 1.04 0.14 0.26 0.92 0.26
93149 BRD-K64857848 HEPG2 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93196 BRD-K64857848 HUVEC 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.06 0.75
93253 BRD-K64857848 JURKAT 10 uM 24 h 0.22 0.92 0.04 0.0 0.0 0.0
93339 BRD-K64857848 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93409 BRD-K64857848 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93435 BRD-K64857848 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93467 BRD-K64857848 SKL 10 uM 24 h 0.23 0.96 0.08 -0.29 -0.99 0.51
93525 BRD-K64857848 THP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93567 BRD-K64857848 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).