CMap Candidate Details

Structure:
CMap ID: C23072
Pert ID: BRD-K64881305
Compound Name: ispinesib
Targets: KIF11
MoA: Kinesin inhibitor
SMILES: CC(C)[C@@H](N(CCCN)C(=O)c1ccc(C)cc1)c1nc2cc(Cl)ccc2c(=O)n1Cc1ccccc1
InchiKey: QJZRFPJCWMNVAV-HHHXNRCGSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
29911 BRD-K64881305 A375 10 uM 6 h 0.0 0.0 0.0 -0.43 -1.43 15.35
30228 BRD-K64881305 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
30514 BRD-K64881305 ASC 10 uM 24 h 0.0 0.0 0.0 0.35 1.24 1.24
30806 BRD-K64881305 HA1E 10 uM 6 h 0.0 0.0 0.0 0.24 0.85 0.14
31101 BRD-K64881305 HCC515 10 uM 6 h 0.0 0.0 0.0 0.32 1.15 0.87
31410 BRD-K64881305 HEPG2 10 uM 6 h 0.28 1.16 0.36 -0.36 -1.21 1.24
31619 BRD-K64881305 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
32057 BRD-K64881305 MCF??7.00 10 uM 6 h -0.23 -0.97 0.11 0.0 0.0 0.0
32215 BRD-K64881305 NEU 10 uM 24 h 0.28 1.19 0.41 -0.32 -1.07 0.78
33097 BRD-K64881305 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33489 BRD-K64881305 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
96948 BRD-K64881305 PC3 1.11 uM 24 h -0.19 -0.81 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).