CMap Candidate Details

Structure:
CMap ID: C23086
Pert ID: BRD-K64925568
Compound Name: AMG-232
Targets: MDM2
MoA: MDM inhibitor
SMILES: CC(C)[C@@H](CS(=O)(=O)C(C)C)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
InchiKey: DRLCSJFKKILATL-YWCVFVGNSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1282 BRD-K64925568 MCF??7.00 10 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
1381 BRD-K64925568 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
124941 BRD-K64925568 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125004 BRD-K64925568 HA1E 0.04 uM 24 h 0.3 1.26 0.58 -0.26 -0.88 0.25
125034 BRD-K64925568 HELA 10 uM 24 h -0.29 -1.21 0.58 -0.26 -0.87 0.24
125116 BRD-K64925568 MDAMB231 0.04 uM 24 h -0.24 -1.0 0.14 0.0 0.0 0.0
125134 BRD-K64925568 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125173 BRD-K64925568 THP1 10 uM 24 h -0.26 -1.06 0.26 0.0 0.0 0.0
125214 BRD-K64925568 YAPC 10 uM 24 h 0.21 0.86 0.01 -0.32 -1.06 0.75
132999 BRD-K64925568 A549 2.22 uM 24 h -0.32 -1.34 0.98 -0.26 -0.88 0.25
133061 BRD-K64925568 HEK293 0.03 uM 24 h 0.0 0.0 0.0 -0.36 -1.22 1.25
133123 BRD-K64925568 HT29 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133168 BRD-K64925568 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.46
133203 BRD-K64925568 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).