CMap Candidate Details

Structure:
CMap ID: C02310
Pert ID: BRD-A95869247
Compound Name: indapamide
Targets: KCNQ1; SLC12A3
MoA: Thiazide diuretic
SMILES: CC1Cc2ccccc2N1NC(=O)c1ccc(Cl)c(c1)S(N)(=O)=O
InchiKey: NDDAHWYSQHTHNT-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8791 BRD-A95869247 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50321 BRD-A95869247 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.22 -0.73 0.05
91435 BRD-A95869247 HUH7 10 uM 72 h 0.23 0.96 0.08 0.0 0.0 0.0
100416 BRD-A95869247 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
128135 BRD-A95869247 A549 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128185 BRD-A95869247 HT29 10 uM 24 h -0.27 -1.14 0.42 0.0 0.0 0.0
128216 BRD-A95869247 MCF10A 0.125 uM 24 h 0.23 0.94 0.06 0.42 1.48 2.24
128295 BRD-A95869247 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135756 BRD-A95869247 A375 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135805 BRD-A95869247 HA1E 0.74 uM 24 h 0.0 0.0 0.0 -0.23 -0.79 0.1
135846 BRD-A95869247 HEK293 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135890 BRD-A95869247 HELA 2.22 uM 24 h 0.29 1.19 0.42 0.0 0.0 0.0
135979 BRD-A95869247 JURKAT 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136025 BRD-A95869247 MCF??7.00 2.22 uM 24 h -0.17 -0.71 0.0 0.22 0.78 0.07
136055 BRD-A95869247 PC3 2.22 uM 24 h 0.24 1.01 0.12 0.25 0.9 0.22
136086 BRD-A95869247 THP1 2.22 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.86
136125 BRD-A95869247 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).