CMap Candidate Details

Structure:
CMap ID: C23109
Pert ID: BRD-K64994968
Compound Name: progesterone
Targets: CYP17A1; NR3C2; PGR
MoA: Progesterone receptor agonist
SMILES: CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
InchiKey: RJKFOVLPORLFTN-LEKSSAKUSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4585 BRD-K64994968 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.21 -0.69 0.03
24466 BRD-K64994968 A375 10 uM 6 h 0.0 0.0 0.0 0.29 1.03 0.52
24597 BRD-K64994968 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
24799 BRD-K64994968 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24934 BRD-K64994968 HT29 10 uM 6 h 0.0 0.0 0.0 0.35 1.23 1.19
25102 BRD-K64994968 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.21 -0.72 0.04
25257 BRD-K64994968 PC3 10 uM 6 h 0.0 0.0 0.0 0.33 1.15 0.89
25525 BRD-K64994968 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.23 -0.76 0.07
39737 BRD-K64994968 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40032 BRD-K64994968 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40845 BRD-K64994968 NEU 10 uM 24 h -0.21 -0.89 0.04 -0.44 -1.48 15.35
41492 BRD-K64994968 SKB 10 uM 24 h -0.25 -1.05 0.24 -0.3 -1.01 0.56
53251 BRD-K64994968 MCF10A 100 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91370 BRD-K64994968 HUH7 10 uM 72 h 0.25 1.03 0.13 0.25 0.9 0.22
99172 BRD-K64994968 NPC 10 uM 24 h 0.0 0.0 0.0 -0.48 -1.62 15.65
99339 BRD-K64994968 U2OS 6.66 uM 6 h 0.21 0.87 0.01 0.26 0.93 0.27
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).