CMap Candidate Details

Structure:
CMap ID: C23181
Pert ID: BRD-K65261396
Compound Name: tacrolimus
Targets: FKBP1A
MoA: Calcineurin inhibitor
SMILES: CO[C@@H]1C[C@@H](CC[C@H]1O)C=C(/C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@H](C[C@@H](C)CC(C)=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]1C)OC
InchiKey: QJJXYPPXXYFBGM-XTNLUGHASA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
29912 BRD-K65261396 A375 10 uM 6 h 0.0 0.0 0.0 0.24 0.84 0.13
30229 BRD-K65261396 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
30515 BRD-K65261396 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
30807 BRD-K65261396 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31411 BRD-K65261396 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31781 BRD-K65261396 HT29 10 uM 6 h 0.0 0.0 0.0 0.36 1.28 1.37
31906 BRD-K65261396 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
32492 BRD-K65261396 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
32810 BRD-K65261396 PC3 10 uM 6 h 0.0 0.0 0.0 0.3 1.08 0.65
33098 BRD-K65261396 SKB 10 uM 24 h -0.24 -0.99 0.14 -0.25 -0.85 0.2
33335 BRD-K65261396 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.67
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).