CMap Candidate Details

Structure:
CMap ID: C02334
Pert ID: BRD-A96754982
Compound Name: tacrolimus
Targets: FKBP1A
MoA: Calcineurin inhibitor
SMILES: CO[C@@H]1CC(CC[C@H]1O)C=C(/C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@H](C[C@@H](C)CC(C)=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]1C)OC
InchiKey: QJJXYPPXXYFBGM-NYOQZLQMSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
128398 BRD-A96754982 A549 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128458 BRD-A96754982 HEK293 1.11 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.77
128515 BRD-A96754982 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128568 BRD-A96754982 JURKAT 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128660 BRD-A96754982 MDAMB231 10 uM 24 h 0.33 1.36 0.97 -0.28 -0.95 0.41
128692 BRD-A96754982 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128740 BRD-A96754982 THP1 10 uM 24 h -0.24 -0.98 0.12 0.0 0.0 0.0
136197 BRD-A96754982 A375 0.03 uM 24 h 0.0 0.0 0.0 0.36 1.27 1.34
136242 BRD-A96754982 HA1E 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136275 BRD-A96754982 HELA 0.74 uM 24 h 0.27 1.14 0.32 0.26 0.92 0.25
136320 BRD-A96754982 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.29 1.04 0.56
136353 BRD-A96754982 MCF??7.00 0.74 uM 24 h 0.31 1.31 0.76 0.0 0.0 0.0
136393 BRD-A96754982 YAPC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).