CMap Candidate Details

Structure:
CMap ID: C23385
Pert ID: BRD-K65928735
Compound Name: AZD-1480
Targets: JAK1; JAK2
MoA: JAK inhibitor
SMILES: C[C@H](Nc1ncc(Cl)c(Nc2cc(C)[nH]n2)n1)c1ncc(F)cn1
InchiKey: PDOQBOJDRPLBQU-QMMMGPOBSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
60 BRD-K65928735 BJAB 0.01 uM 4 h 0.19 0.79 0.0 -0.19 -0.64 0.01
94 BRD-K65928735 HBL1 0.66 uM 24 h 0.22 0.94 0.05 0.35 1.25 1.28
129 BRD-K65928735 K562 2.5 uM 24 h -0.23 -0.96 0.1 0.0 0.0 0.0
184 BRD-K65928735 KMS34 10 uM 24 h 0.0 0.0 0.0 0.34 1.2 1.1
224 BRD-K65928735 NALM6 0.66 uM 24 h 0.0 0.0 0.0 -0.28 -0.96 0.42
263 BRD-K65928735 OCILY10 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
289 BRD-K65928735 OCILY19 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
338 BRD-K65928735 OCILY3 10 uM 24 h -0.28 -1.15 0.44 0.0 0.0 0.0
382 BRD-K65928735 SKMEL5 2.5 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.14
408 BRD-K65928735 THP1 10 uM 24 h -0.31 -1.31 0.82 -0.29 -0.96 0.44
445 BRD-K65928735 TMD8 10 uM 24 h 0.2 0.84 0.0 0.22 0.78 0.07
90849 BRD-K65928735 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124944 BRD-K65928735 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124978 BRD-K65928735 A549 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125007 BRD-K65928735 HA1E 0.04 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.18
125038 BRD-K65928735 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125120 BRD-K65928735 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.4 1.42 2.19
125220 BRD-K65928735 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133068 BRD-K65928735 HEK293 0.25 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.5
133128 BRD-K65928735 HT29 0.03 uM 24 h -0.2 -0.82 0.0 -0.25 -0.83 0.16
133175 BRD-K65928735 JURKAT 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133238 BRD-K65928735 MCF??7.00 0.08 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.57
133298 BRD-K65928735 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.21 0.75 0.04
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).