CMap Candidate Details

Structure:
CMap ID: C23444
Pert ID: BRD-K66175015
Compound Name: afatinib
Targets: EGFR; ERBB2; ERBB4
MoA: EGFR inhibitor
SMILES: CN(C)CC=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1
InchiKey: ULXXDDBFHOBEHA-CWDCEQMOSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9 BRD-K66175015 NCIH2073 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
17 BRD-K66175015 NCIH508 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
26 BRD-K66175015 NCIH596 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.79 0.1
33 BRD-K66175015 SKBR3 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
59 BRD-K66175015 BJAB 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
93 BRD-K66175015 HBL1 2.5 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.56
153 BRD-K66175015 K562 2.5 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
183 BRD-K66175015 KMS34 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
223 BRD-K66175015 NALM6 2.5 uM 24 h -0.21 -0.86 0.02 0.0 0.0 0.0
262 BRD-K66175015 OCILY10 2.5 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.65
288 BRD-K66175015 OCILY19 2.5 uM 24 h 0.0 0.0 0.0 -0.45 -1.5 15.35
337 BRD-K66175015 OCILY3 10 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
381 BRD-K66175015 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
424 BRD-K66175015 THP1 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
444 BRD-K66175015 TMD8 2.5 uM 24 h -0.26 -1.06 0.26 0.0 0.0 0.0
1276 BRD-K66175015 MCF??7.00 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1337 BRD-K66175015 U2OS 1.11 uM 24 h 0.28 1.17 0.36 0.0 0.0 0.0
30517 BRD-K66175015 ASC 10 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.62
31617 BRD-K66175015 HT29 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.0 0.54
32217 BRD-K66175015 NEU 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.92
33100 BRD-K66175015 SKB 10 uM 24 h 0.2 0.84 0.0 0.25 0.88 0.18
33336 BRD-K66175015 VCAP 10 uM 24 h 0.19 0.8 0.0 -0.29 -0.96 0.44
82979 BRD-K66175015 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118203 BRD-K66175015 HEPG2 3.33 uM 24 h 0.23 0.94 0.06 -0.2 -0.69 0.02
125039 BRD-K66175015 HELA 10 uM 24 h -0.22 -0.92 0.06 0.0 0.0 0.0
125121 BRD-K66175015 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.31 1.09 0.67
125139 BRD-K66175015 PC3 3.33 uM 24 h 0.18 0.76 0.0 0.0 0.0 0.0
132985 BRD-K66175015 A375 2.22 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.68
133001 BRD-K66175015 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133020 BRD-K66175015 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133069 BRD-K66175015 HEK293 2.22 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.39
133176 BRD-K66175015 JURKAT 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133208 BRD-K66175015 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133322 BRD-K66175015 YAPC 0.74 uM 24 h 0.2 0.84 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).