CMap Candidate Details

Structure:
CMap ID: C23486
Pert ID: BRD-K66296774
Compound Name: fluvastatin
Targets: HMGCR
MoA: HMGCR inhibitor
SMILES: CC(C)n1c(C=C[C@@H](O)C[C@@H](O)CC(O)=O)c(-c2ccc(F)cc2)c2ccccc12
InchiKey: FJLGEFLZQAZZCD-MCBHFWOFSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1427 BRD-K66296774 NPC 25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5352 BRD-K66296774 HA1E 10 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.62
5665 BRD-K66296774 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6049 BRD-K66296774 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6407 BRD-K66296774 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37713 BRD-K66296774 ASC 10 uM 24 h -0.29 -1.2 0.56 0.0 0.0 0.0
37932 BRD-K66296774 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.24 -0.81 0.14
38216 BRD-K66296774 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38760 BRD-K66296774 PHH 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.89 0.27
38988 BRD-K66296774 SKB 10 uM 24 h 0.25 1.04 0.15 -0.2 -0.67 0.01
91180 BRD-K66296774 HUH7 8 uM 72 h 0.0 0.0 0.0 0.27 0.96 0.33
95547 BRD-K66296774 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95636 BRD-K66296774 U2OS 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96319 BRD-K66296774 A375 3.33 uM 24 h -0.26 -1.08 0.31 -0.35 -1.18 1.14
96390 BRD-K66296774 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98539 BRD-K66296774 NEU 10 uM 6 h 0.28 1.18 0.39 -0.34 -1.14 1.02
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).