CMap Candidate Details

Structure:
CMap ID: C02350
Pert ID: BRD-A97674275
Compound Name: ranolazine
Targets: SCN5A; SCN9A
MoA: Sodium channel blocker
SMILES: COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1
InchiKey: XKLMZUWKNUAPSZ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4325 BRD-A97674275 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4867 BRD-A97674275 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
24739 BRD-A97674275 HA1E 10 uM 6 h 0.0 0.0 0.0 -0.47 -1.59 15.65
37570 BRD-A97674275 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37863 BRD-A97674275 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38409 BRD-A97674275 NPC 10 uM 24 h -0.21 -0.87 0.02 0.0 0.0 0.0
38676 BRD-A97674275 PHH 10 uM 24 h 0.0 0.0 0.0 -0.3 -0.99 0.51
38899 BRD-A97674275 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91411 BRD-A97674275 HUH7 8 uM 72 h -0.27 -1.11 0.37 0.25 0.89 0.21
128112 BRD-A97674275 A375 10 uM 24 h 0.25 1.05 0.16 0.0 0.0 0.0
128171 BRD-A97674275 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128187 BRD-A97674275 HT29 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128229 BRD-A97674275 MCF10A 3.33 uM 24 h -0.2 -0.84 0.01 0.0 0.0 0.0
128263 BRD-A97674275 MCF??7.00 10 uM 24 h -0.19 -0.8 0.0 0.32 1.12 0.76
128308 BRD-A97674275 MDAMB231 3.33 uM 24 h 0.26 1.09 0.23 0.35 1.26 1.29
135779 BRD-A97674275 A549 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135903 BRD-A97674275 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135992 BRD-A97674275 JURKAT 0.03 uM 24 h -0.31 -1.3 0.81 -0.35 -1.18 1.15
136063 BRD-A97674275 PC3 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136093 BRD-A97674275 THP1 2.22 uM 24 h 0.26 1.09 0.23 -0.23 -0.78 0.1
136138 BRD-A97674275 YAPC 0.74 uM 24 h -0.25 -1.05 0.23 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).