CMap Candidate Details

Structure:
CMap ID: C23512
Pert ID: BRD-K66404838
Compound Name: nalbuphine
Targets: OPRD1; OPRK1; OPRM1
MoA: Opioid receptor agonist; Opioid receptor antagonist
SMILES: O[C@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC1CCC1)c45
InchiKey: NETZHAKZCGBWSS-CEDHKZHLSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8721 BRD-K66404838 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91046 BRD-K66404838 HUH7 10 uM 72 h -0.18 -0.74 0.0 0.0 0.0 0.0
95350 BRD-K66404838 MCF??7.00 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95459 BRD-K66404838 U2OS 10 uM 6 h 0.0 0.0 0.0 -0.39 -1.31 1.71
124947 BRD-K66404838 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124982 BRD-K66404838 A549 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125061 BRD-K66404838 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125084 BRD-K66404838 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125123 BRD-K66404838 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.28 1.0 0.42
125182 BRD-K66404838 THP1 10 uM 24 h -0.23 -0.95 0.09 0.29 1.01 0.45
133022 BRD-K66404838 HA1E 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133072 BRD-K66404838 HEK293 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133099 BRD-K66404838 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133301 BRD-K66404838 PC3 2.22 uM 24 h 0.26 1.08 0.21 0.0 0.0 0.0
133325 BRD-K66404838 YAPC 2.22 uM 24 h 0.22 0.93 0.05 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).