CMap Candidate Details

Structure:
CMap ID: C23544
Pert ID: BRD-K66538826
Compound Name: amuvatinib
Targets: FLT3; KIT; MET; PDGFRA
MoA: KIT inhibitor; FLT3 inhibitor; PDGFR inhibitor; RAD51 inhibitor; RET tyrosine kinase inhibitor
SMILES: S=C(NCc1ccc2OCOc2c1)N1CCN(CC1)c1ncnc2c3ccccc3oc12
InchiKey: FOFDIMHVKGYHRU-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91822 BRD-K66538826 HS578T 0.08 uM 6 h 0.28 1.15 0.34 -0.26 -0.88 0.24
91970 BRD-K66538826 SKBR3 0.08 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
92913 BRD-K66538826 ASC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92970 BRD-K66538826 CD34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93028 BRD-K66538826 HA1E 10 uM 24 h -0.3 -1.26 0.72 0.0 0.0 0.0
93061 BRD-K66538826 HEK293 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.75 0.06
93150 BRD-K66538826 HEPG2 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.86
93197 BRD-K66538826 HUVEC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93254 BRD-K66538826 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
93380 BRD-K66538826 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93502 BRD-K66538826 SKL 0.04 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.35
93526 BRD-K66538826 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95431 BRD-K66538826 U2OS 10 uM 48 h 0.0 0.0 0.0 -0.33 -1.1 0.88
124980 BRD-K66538826 A549 10 uM 24 h 0.0 0.0 0.0 -0.3 -0.99 0.51
125060 BRD-K66538826 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125082 BRD-K66538826 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125221 BRD-K66538826 YAPC 10 uM 24 h -0.28 -1.17 0.48 0.0 0.0 0.0
132986 BRD-K66538826 A375 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133098 BRD-K66538826 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133240 BRD-K66538826 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133269 BRD-K66538826 MDAMB231 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133300 BRD-K66538826 PC3 2.22 uM 24 h -0.25 -1.04 0.21 -0.35 -1.19 1.15
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).