CMap Candidate Details

Structure:
CMap ID: C02355
Pert ID: BRD-A97808748
Compound Name: spironolactone
Targets: NR3C2
MoA: Mineralocorticoid receptor antagonist
SMILES: CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]33CCC(=O)O3)C12
InchiKey: LXMSZDCAJNLERA-SRFJPPJVSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
128122 BRD-A97808748 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128152 BRD-A97808748 A549 10 uM 24 h -0.19 -0.8 0.0 0.0 0.0 0.0
128175 BRD-A97808748 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128244 BRD-A97808748 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128272 BRD-A97808748 MCF??7.00 10 uM 24 h -0.27 -1.14 0.42 0.0 0.0 0.0
128323 BRD-A97808748 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128364 BRD-A97808748 THP1 10 uM 24 h -0.22 -0.92 0.06 0.0 0.0 0.0
135828 BRD-A97808748 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.24
135918 BRD-A97808748 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135956 BRD-A97808748 HT29 0.08 uM 24 h 0.0 0.0 0.0 0.23 0.81 0.09
136008 BRD-A97808748 JURKAT 0.08 uM 24 h 0.0 0.0 0.0 -0.42 -1.43 15.35
136069 BRD-A97808748 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.21 0.75 0.04
136154 BRD-A97808748 YAPC 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).