CMap Candidate Details

Structure:
CMap ID: C23688
Pert ID: BRD-K66911501
Compound Name: MK-3207
Targets: CALCRL; CALCA
MoA: Calcitonin antagonist
SMILES: Fc1cc(F)cc(c1)[C@@H]1CNC2(CCCC2)C(=O)N1CC(=O)Nc1ccc2C[C@]3(Cc2c1)C(=O)Nc1ncccc31
InchiKey: AZAANWYREOQRFB-SETSBSEESA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
124948 BRD-K66911501 A375 0.37 uM 24 h 0.21 0.86 0.01 -0.34 -1.16 1.11
124983 BRD-K66911501 A549 0.125 uM 24 h 0.24 0.99 0.09 0.0 0.0 0.0
125010 BRD-K66911501 HA1E 0.125 uM 24 h 0.31 1.29 0.67 0.0 0.0 0.0
125124 BRD-K66911501 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125140 BRD-K66911501 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125185 BRD-K66911501 THP1 1.11 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.73
133075 BRD-K66911501 HEK293 0.25 uM 24 h -0.21 -0.86 0.02 -0.38 -1.27 1.43
133102 BRD-K66911501 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.63
133131 BRD-K66911501 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.22 0.79 0.07
133181 BRD-K66911501 JURKAT 0.01 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.45
133210 BRD-K66911501 MCF10A 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133243 BRD-K66911501 MCF??7.00 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133326 BRD-K66911501 YAPC 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).