CMap Candidate Details

Structure:
CMap ID: C02373
Pert ID: BRD-A98702003
Compound Name: carbenoxolone
Targets: HSD11B1
MoA: 11-beta-HSD1 inhibitor
SMILES: CC1(C)[C@H](CC[C@@]2(C)C1CC[C@]1(C)C2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(=O)CCC(O)=O
InchiKey: OBZHEBDUNPOCJG-YQNKGXRGSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4179 BRD-A98702003 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
4327 BRD-A98702003 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.76
4870 BRD-A98702003 VCAP 10 uM 24 h 0.22 0.9 0.02 -0.29 -0.98 0.49
37573 BRD-A98702003 ASC 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.39
37865 BRD-A98702003 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.06 0.73
38412 BRD-A98702003 NPC 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.26 1.35
38901 BRD-A98702003 SKB 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.54
99937 BRD-A98702003 U2OS 10 uM 6 h 0.0 0.0 0.0 0.28 0.99 0.39
127348 BRD-A98702003 A375 3.33 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.22
127388 BRD-A98702003 A549 1.11 uM 24 h 0.0 0.0 0.0 0.35 1.24 1.25
127462 BRD-A98702003 HELA 0.125 uM 24 h -0.27 -1.12 0.38 0.0 0.0 0.0
127511 BRD-A98702003 JURKAT 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127603 BRD-A98702003 PC3 1.11 uM 24 h -0.25 -1.04 0.21 -0.28 -0.93 0.35
127681 BRD-A98702003 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135398 BRD-A98702003 HT29 2.22 uM 24 h -0.24 -1.0 0.15 0.0 0.0 0.0
135436 BRD-A98702003 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135470 BRD-A98702003 MCF??7.00 0.03 uM 24 h 0.0 0.0 0.0 0.32 1.15 0.88
135496 BRD-A98702003 THP1 0.25 uM 24 h -0.28 -1.15 0.43 0.3 1.05 0.57
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).