CMap Candidate Details

Structure:
CMap ID: C02375
Pert ID: BRD-A98725278
Compound Name: methysergide
Targets: HTR1B; HTR1E; HTR1F; HTR2A; HTR2B; HTR2C; HTR7
MoA: Serotonin receptor antagonist
SMILES: CCC(CO)NC(=O)C1CN(C)C2Cc3cn(C)c4cccc(C2=C1)c34
InchiKey: KPJZHOPZRAFDTN-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1718 BRD-A98725278 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
1862 BRD-A98725278 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2245 BRD-A98725278 PC3 10 uM 24 h 0.0 0.0 0.0 0.23 0.83 0.11
2570 BRD-A98725278 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42039 BRD-A98725278 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42254 BRD-A98725278 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42590 BRD-A98725278 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42896 BRD-A98725278 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43141 BRD-A98725278 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43451 BRD-A98725278 NPC 10 uM 24 h -0.16 -0.68 0.0 0.26 0.93 0.27
43757 BRD-A98725278 PHH 10 uM 24 h 0.27 1.13 0.28 0.35 1.24 1.25
44041 BRD-A98725278 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99938 BRD-A98725278 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).