CMap Candidate Details

Structure:
CMap ID: C23804
Pert ID: BRD-K67277431
Compound Name: picotamide
Targets: TBXA2R
MoA: Thromboxane synthase inhibitor; Thromboxane receptor antagonist
SMILES: COc1ccc(cc1C(=O)NCc1cccnc1)C(=O)NCc1cccnc1
InchiKey: KYWCWBXGRWWINE-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1948 BRD-K67277431 HCC515 10 uM 24 h -0.25 -1.05 0.22 0.0 0.0 0.0
2682 BRD-K67277431 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.99 0.5
42443 BRD-K67277431 ASC 10 uM 24 h 0.25 1.05 0.17 0.0 0.0 0.0
42757 BRD-K67277431 HEPG2 10 uM 6 h 0.24 1.0 0.11 0.0 0.0 0.0
43622 BRD-K67277431 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43924 BRD-K67277431 PHH 10 uM 24 h 0.0 0.0 0.0 0.37 1.32 1.68
44178 BRD-K67277431 SKB 10 uM 24 h 0.23 0.94 0.06 0.4 1.43 2.2
91418 BRD-K67277431 HUH7 8 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
124988 BRD-K67277431 A549 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125043 BRD-K67277431 HELA 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125126 BRD-K67277431 MDAMB231 0.04 uM 24 h 0.24 1.01 0.12 0.26 0.92 0.25
125191 BRD-K67277431 THP1 10 uM 24 h -0.3 -1.26 0.71 0.21 0.73 0.03
125226 BRD-K67277431 YAPC 0.125 uM 24 h 0.19 0.8 0.0 0.0 0.0 0.0
132991 BRD-K67277431 A375 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133027 BRD-K67277431 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133080 BRD-K67277431 HEK293 2.22 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.75
133135 BRD-K67277431 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133212 BRD-K67277431 MCF10A 0.01 uM 24 h 0.0 0.0 0.0 0.21 0.75 0.04
133249 BRD-K67277431 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133307 BRD-K67277431 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).