CMap Candidate Details

Structure:
CMap ID: C02383
Pert ID: BRD-A99117172
Compound Name: hydroxychloroquine
Targets: TLR7; TLR9
MoA: Anti-malarial agent
SMILES: CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
InchiKey: XXSMGPRMXLTPCZ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
484 BRD-A99117172 BJAB 0.66 uM 24 h 0.28 1.16 0.35 0.0 0.0 0.0
528 BRD-A99117172 HBL1 0.66 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.57
570 BRD-A99117172 K562 10 uM 24 h -0.22 -0.93 0.07 -0.28 -0.95 0.41
622 BRD-A99117172 KMS34 0.04 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
667 BRD-A99117172 MINO 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
715 BRD-A99117172 NALM6 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
784 BRD-A99117172 OCILY19 0.04 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
826 BRD-A99117172 OCILY3 10 uM 4 h -0.21 -0.88 0.03 0.0 0.0 0.0
856 BRD-A99117172 SKMEL5 2.5 uM 24 h 0.0 0.0 0.0 0.37 1.31 1.59
902 BRD-A99117172 THP1 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
935 BRD-A99117172 TMD8 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
51580 BRD-A99117172 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.22 0.77 0.06
51793 BRD-A99117172 PC3 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.41
98988 BRD-A99117172 NEU 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
99121 BRD-A99117172 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).