CMap Candidate Details

Structure:
CMap ID: C23891
Pert ID: BRD-K67537649
Compound Name: PQ-401
Targets: IGF1R
MoA: IGF-1 inhibitor
SMILES: COc1ccc(Cl)cc1NC(=O)Nc1cc(C)nc2ccccc12
InchiKey: YBLWOZUPHDKFOT-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4236 BRD-K67537649 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
4464 BRD-K67537649 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4706 BRD-K67537649 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4951 BRD-K67537649 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.51
39474 BRD-K67537649 A549 10 uM 6 h 0.21 0.87 0.01 0.0 0.0 0.0
39743 BRD-K67537649 ASC 10 uM 24 h 0.22 0.9 0.03 0.0 0.0 0.0
40037 BRD-K67537649 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.08 0.81
40306 BRD-K67537649 HT29 10 uM 6 h 0.0 0.0 0.0 0.28 0.99 0.4
40494 BRD-K67537649 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.45 -1.53 15.35
40849 BRD-K67537649 NEU 10 uM 24 h -0.29 -1.21 0.58 -0.34 -1.14 1.02
41160 BRD-K67537649 NPC 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.19 1.16
41498 BRD-K67537649 SKB 10 uM 24 h 0.24 1.01 0.12 0.0 0.0 0.0
97292 BRD-K67537649 HAP1 3.33 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.69
97346 BRD-K67537649 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99370 BRD-K67537649 U2OS 10 uM 6 h 0.26 1.09 0.24 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).