CMap Candidate Details

Structure:
CMap ID: C23991
Pert ID: BRD-K67844266
Compound Name: MLN-4924
Targets: --
MoA: --
SMILES: NS(=O)(=O)OC[C@@H]1C[C@H](C[C@@H]1O)n1ccc2c(N[C@H]3CCc4ccccc34)ncnc12
InchiKey: MPUQHZXIXSTTDU-QXGSTGNESA-N
Compound Aliases: pevonedistat

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
497 BRD-K67844266 BJAB 0.04 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.58
556 BRD-K67844266 HBL1 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
575 BRD-K67844266 K562 0.04 uM 24 h 0.0 0.0 0.0 -0.45 -1.51 15.35
635 BRD-K67844266 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
681 BRD-K67844266 MINO 0.01 uM 24 h 0.27 1.13 0.28 0.31 1.11 0.73
728 BRD-K67844266 NALM6 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
763 BRD-K67844266 OCILY19 0.01 uM 24 h 0.26 1.06 0.19 0.0 0.0 0.0
833 BRD-K67844266 OCILY3 10 uM 4 h 0.0 0.0 0.0 -0.36 -1.2 1.16
870 BRD-K67844266 SKMEL5 0.04 uM 24 h 0.0 0.0 0.0 -0.34 -1.16 1.11
912 BRD-K67844266 THP1 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
965 BRD-K67844266 TMD8 0.66 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
9040 BRD-K67844266 A375 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9479 BRD-K67844266 AGS 12 uM 6 h 0.0 0.0 0.0 -0.38 -1.29 1.53
9784 BRD-K67844266 H1299 12 uM 6 h -0.25 -1.04 0.21 -0.21 -0.71 0.04
10072 BRD-K67844266 HA1E 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10305 BRD-K67844266 HCC515 12 uM 6 h -0.3 -1.25 0.71 0.25 0.89 0.2
10826 BRD-K67844266 HEPG2 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11290 BRD-K67844266 MCF??7.00 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11545 BRD-K67844266 NCIH2073 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11811 BRD-K67844266 NCIH508 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12103 BRD-K67844266 NCIH596 12 uM 6 h 0.0 0.0 0.0 -0.28 -0.96 0.42
12620 BRD-K67844266 PC3 12 uM 6 h 0.0 0.0 0.0 0.2 0.72 0.03
12844 BRD-K67844266 SW480 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13330 BRD-K67844266 U937 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13659 BRD-K67844266 VCAP 12 uM 6 h 0.0 0.0 0.0 -0.33 -1.12 0.94
90643 BRD-K67844266 HCT116 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90692 BRD-K67844266 MCF10A 0.125 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.61
95993 BRD-K67844266 PHH 10 uM 24 h 0.0 0.0 0.0 0.41 1.44 2.21
97588 BRD-K67844266 NKDBA 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98086 BRD-K67844266 P1A82 3.33 uM 24 h 0.24 1.02 0.12 0.0 0.0 0.0
126445 BRD-K67844266 HEK293 10 uM 24 h 0.0 0.0 0.0 -0.42 -1.4 2.02
134380 BRD-K67844266 A549 0.74 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.75
134433 BRD-K67844266 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.21 0.75 0.04
134469 BRD-K67844266 HT29 0.25 uM 24 h 0.0 0.0 0.0 0.42 1.49 2.25
134512 BRD-K67844266 HUVEC 0.74 uM 24 h 0.31 1.31 0.76 0.0 0.0 0.0
134604 BRD-K67844266 MDAMB231 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134655 BRD-K67844266 YAPC 2.22 uM 24 h 0.22 0.9 0.02 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).