CMap Candidate Details

Structure:
CMap ID: C24115
Pert ID: BRD-K68232650
Compound Name: lacosamide
Targets: SCN1A; SCN3A; SCN9A; SCN10A
MoA: Sodium channel blocker; Collapsin response mediator protein inhibitor; Collapsin response mediator protein stimulant
SMILES: COC[C@@H](NC(C)=O)C(=O)NCc1ccccc1
InchiKey: VPPJLAIAVCUEMN-GFCCVEGCSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
126619 BRD-K68232650 A375 0.37 uM 24 h -0.22 -0.9 0.04 0.0 0.0 0.0
126685 BRD-K68232650 HEK293 1.11 uM 24 h -0.22 -0.91 0.05 0.26 0.91 0.23
126706 BRD-K68232650 HELA 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126794 BRD-K68232650 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126826 BRD-K68232650 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126868 BRD-K68232650 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126929 BRD-K68232650 THP1 10 uM 24 h -0.29 -1.21 0.57 -0.21 -0.72 0.04
126980 BRD-K68232650 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.32 1.14 0.85
134691 BRD-K68232650 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134717 BRD-K68232650 HA1E 2.22 uM 24 h 0.27 1.11 0.25 0.0 0.0 0.0
134815 BRD-K68232650 HT29 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134844 BRD-K68232650 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134895 BRD-K68232650 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.59
134953 BRD-K68232650 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).