CMap Candidate Details

Structure:
CMap ID: C24154
Pert ID: BRD-K68332390
Compound Name: ponalrestat
Targets: AKR1B1
MoA: Aldose reductase inhibitor
SMILES: OC(=O)Cc1nn(Cc2ccc(Br)cc2F)c(=O)c3ccccc13
InchiKey: LKBFFDOJUKLQNY-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1771 BRD-K68332390 HA1E 10 uM 6 h 0.19 0.78 0.0 -0.23 -0.77 0.08
1951 BRD-K68332390 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2251 BRD-K68332390 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2732 BRD-K68332390 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
41829 BRD-K68332390 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42132 BRD-K68332390 A549 10 uM 6 h 0.0 0.0 0.0 -0.36 -1.21 1.24
42447 BRD-K68332390 ASC 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.56
42760 BRD-K68332390 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.22 -0.74 0.05
43059 BRD-K68332390 HT29 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.01 0.57
43227 BRD-K68332390 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43625 BRD-K68332390 NPC 10 uM 24 h -0.25 -1.06 0.26 0.0 0.0 0.0
44182 BRD-K68332390 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99383 BRD-K68332390 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).