CMap Candidate Details

Structure:
CMap ID: C24178
Pert ID: BRD-K68407802
Compound Name: KIN001-055
Targets: JAK3
MoA: JAK inhibitor; EGFR inhibitor; Leukotriene inhibitor; Mediator release inhibitor
SMILES: COc1cc2ncnc(Nc3cc(Br)c(O)c(Br)c3)c2cc1OC
InchiKey: YVCXQRVVNQMZEI-UHFFFAOYSA-N
Compound Aliases: KIN-001-055

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33832 BRD-K68407802 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34406 BRD-K68407802 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34667 BRD-K68407802 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34940 BRD-K68407802 HEPG2 10 uM 6 h -0.24 -0.98 0.13 0.0 0.0 0.0
36325 BRD-K68407802 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36623 BRD-K68407802 SKB 10 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.23
36994 BRD-K68407802 VCAP 10 uM 6 h -0.29 -1.2 0.55 -0.26 -0.87 0.23
91521 BRD-K68407802 BT20 2.22 uM 24 h 0.0 0.0 0.0 0.34 1.21 1.15
91584 BRD-K68407802 HS578T 0.37 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.75
91664 BRD-K68407802 MCF??7.00 0.37 uM 24 h 0.19 0.77 0.0 -0.2 -0.69 0.02
91695 BRD-K68407802 MDAMB231 0.08 uM 24 h 0.21 0.89 0.02 0.25 0.9 0.21
91777 BRD-K68407802 SKBR3 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
94428 BRD-K68407802 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94499 BRD-K68407802 ASC 1.11 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.25
94575 BRD-K68407802 CD34 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94663 BRD-K68407802 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94710 BRD-K68407802 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94770 BRD-K68407802 HME1 10 uM 24 h 0.0 0.0 0.0 0.32 1.14 0.86
94808 BRD-K68407802 HT29 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.25 1.35
94861 BRD-K68407802 HUVEC 1.11 uM 24 h 0.0 0.0 0.0 0.29 1.01 0.45
94913 BRD-K68407802 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94957 BRD-K68407802 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95039 BRD-K68407802 NEU 3.33 uM 24 h -0.22 -0.92 0.06 0.0 0.0 0.0
95065 BRD-K68407802 NPC 1.11 uM 24 h -0.21 -0.88 0.03 0.0 0.0 0.0
95134 BRD-K68407802 PC3 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.14
95188 BRD-K68407802 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95223 BRD-K68407802 SKL 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95297 BRD-K68407802 THP1 1.11 uM 24 h 0.0 0.0 0.0 0.32 1.13 0.84
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).