CMap Candidate Details

Structure:
CMap ID: C24200
Pert ID: BRD-K68488863
Compound Name: ENMD-2076
Targets: FLT3; KDR; PDGFRA; SRC; AURKA
MoA: FLT3 inhibitor; VEGFR inhibitor; Aurora kinase inhibitor
SMILES: CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(C=Cc2ccccc2)n1
InchiKey: BLQYVHBZHAISJM-CMDGGOBGSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
95624 BRD-K68488863 U2OS 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119186 BRD-K68488863 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119215 BRD-K68488863 A549 10 uM 24 h 0.0 0.0 0.0 0.34 1.19 1.03
119274 BRD-K68488863 HCC515 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119303 BRD-K68488863 HEPG2 3.33 uM 24 h 0.0 0.0 0.0 -0.22 -0.75 0.06
119329 BRD-K68488863 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126449 BRD-K68488863 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126527 BRD-K68488863 MCF10A 3.33 uM 24 h 0.21 0.88 0.02 -0.33 -1.1 0.87
126559 BRD-K68488863 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134408 BRD-K68488863 HA1E 0.03 uM 24 h 0.0 0.0 0.0 -0.25 -0.83 0.17
134436 BRD-K68488863 HELA 2.22 uM 24 h 0.0 0.0 0.0 -0.31 -1.06 0.73
134516 BRD-K68488863 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 -0.4 -1.35 2.02
134573 BRD-K68488863 MCF??7.00 0.74 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.78
134630 BRD-K68488863 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134656 BRD-K68488863 YAPC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).