CMap Candidate Details

Structure:
CMap ID: C24213
Pert ID: BRD-K68532323
Compound Name: SB-743921
Targets: KIF11
MoA: Kinesin-like spindle protein inhibitor
SMILES: CC(C)[C@@H](N(CCCN)C(=O)c1ccc(C)cc1)c1oc2cc(Cl)ccc2c(=O)c1Cc1ccccc1
InchiKey: PGXYIBJJCLWJST-MUUNZHRXSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
116307 BRD-K68532323 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116348 BRD-K68532323 A549 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116391 BRD-K68532323 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.29 1.03 0.52
116439 BRD-K68532323 HCC515 0.04 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.34
116492 BRD-K68532323 HEPG2 0.04 uM 24 h -0.25 -1.02 0.18 0.0 0.0 0.0
116625 BRD-K68532323 PC3 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.15
126418 BRD-K68532323 HEK293 1.11 uM 24 h 0.0 0.0 0.0 -0.36 -1.21 1.24
126466 BRD-K68532323 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126489 BRD-K68532323 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126509 BRD-K68532323 MCF10A 10 uM 24 h -0.22 -0.93 0.07 -0.38 -1.27 1.43
134485 BRD-K68532323 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134558 BRD-K68532323 MCF??7.00 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134586 BRD-K68532323 MDAMB231 0.08 uM 24 h 0.18 0.74 0.0 0.0 0.0 0.0
134644 BRD-K68532323 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).