CMap Candidate Details

Structure:
CMap ID: C02426
Pert ID: BRD-K00077635
Compound Name: estramustine-phosphate
Targets: ESR1; ESR2; MAP1A; MAP2
MoA: DNA inhibitor; DNA alkylating agent; Microtubule inhibitor; DNA synthesis inhibitor; Estrogen receptor agonist
SMILES: C[C@]12CC[C@H]3[C@@H](CCc4cc(OC(=O)N(CCCl)CCCl)ccc34)[C@@H]1CC[C@@H]2OP(O)(O)=O
InchiKey: ADFOJJHRTBFFOF-RBRWEJTLSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
122827 BRD-K00077635 A375 0.37 uM 24 h 0.0 0.0 0.0 -0.27 -0.89 0.27
122871 BRD-K00077635 HEK293 0.04 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.12
122925 BRD-K00077635 HELA 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122956 BRD-K00077635 HT29 10 uM 24 h 0.0 0.0 0.0 -0.4 -1.36 2.02
122996 BRD-K00077635 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123050 BRD-K00077635 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123068 BRD-K00077635 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123085 BRD-K00077635 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123157 BRD-K00077635 THP1 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131223 BRD-K00077635 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131266 BRD-K00077635 HA1E 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131333 BRD-K00077635 HUVEC 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131450 BRD-K00077635 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131478 BRD-K00077635 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).