CMap Candidate Details

Structure:
CMap ID: C24299
Pert ID: BRD-K68783079
Compound Name: BRD-K68783079
Targets: CLK1; DYRK1A; CLK4
MoA: CLK inhibitor; DYRK inhibitor
SMILES: Cc1nc(CNc2ncnc3ccc(cc23)-c2ccc3OCOc3c2)cs1
InchiKey: LELRIWOVACJYND-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
16444 BRD-K68783079 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
16749 BRD-K68783079 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
17076 BRD-K68783079 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
17412 BRD-K68783079 HEPG2 10 uM 6 h 0.21 0.87 0.01 0.0 0.0 0.0
17754 BRD-K68783079 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
18488 BRD-K68783079 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
18820 BRD-K68783079 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.04 0.65
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).